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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Biochem J. 2007 May 15;404(1):1–13. doi: 10.1042/BJ20070140

Figure 1. Sirtuin enzymatic activities.

Figure 1

Sirtuins are NAD+-dependent deacetylases and mono-ADP-ribosyl transferases that regulate a wide array of proteins involved in metabolism and cell survival. The ε-acetyl lysine residues of the target protein serve as substrates for sirtuin deacetylation, which generate 2′-OAADPr as a by-product. NAM, nicotinamide.