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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Heart Rhythm. 2009 May 18;6(9):1318–1326. doi: 10.1016/j.hrthm.2009.05.016

Figure 4.

Figure 4

Hyperthermic effects on the gating kinetics of WT-delQ and V1340I-delQ. (A) Superimposed whole-cell current traces induced by step-pulse protocols from a holding potential of −140 mV at 40°C. (B) I–V relationships at 40°C. (C) Voltage dependency of the steady-state activation and the fast inactivation at 40°C. (D) Representative superimposed current traces obtained from the cells expressing WT-delQ or V1340I-delQ at 3 different temperatures. The currents were induced with a depolarization pulse protocol. (E) Bar graphs of WT-delQ and V1340I-delQ current densities at various temperatures. Data are presented as mean ± SD. *P <.005 vs. 22°C; †P <.005 vs. V1340I; ‡P <.01 vs. 22°C.