Figure 3.
Activity summary for ring-substituted β-aminophenylketones: Heatmap shows IC50 values for the inhibition of coregulatory peptide binding (SRC2-2) by TRβ, EC50 values for cellular proliferation inhibition (HepG2), and calculated therapeutic index (TI, ratio of two prior values). Compound order is sorted by therapeutic index. aValues are the mean of three independent experiments in triplicate. bValues are means of two independent experiments in triplicate. cValues are EC50 over IC50.