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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Curr Opin Mol Ther. 2009 Apr;11(2):116–123.

Figure 1. Schematic demonstration of antisense-mediated splicing modulation.

Figure 1

(A) Antisense oligonucleotide (AO) blocking of a mutation-induced cryptic 5′ splicing site (SS). (B) AO blocking of exon-intron junctions and/or exonic splicing enhancer (ESE) site to induce exon skipping. (C) AO blocking of exonic splicing silencer (ESS) or intronic splicing silencer (ISS) sites to enhance exon inclusion.