Table 2. Pairwise correlations (r) and heritability estimates (h ²) of antibody isotype responses to P. falciparum blood stage antigens for child twins (dry season).

Antibody	Antigens	Monozygous r (n = 32)	Dizygous r (n = 167)	Heritability h 2	95% CI	P value
IgG1	AMA1	0.83	0.50	0.76	0.52–0.92	0.0001
	MSP1-19	0.34	0.34	0	0.0–0.53	-
	MSP2A	0.73	0.46	0.73	0.39–0.88	0.001
	MSP2B	0.75	0.59	0.53	0.13–0.87	0.01
	MSP3A	0.81	0.40	0.87	0.67–0.92	0.0001
	MSP3B	0.51	0.39	0.32	0.0–0.71	0.27
IgG2	AMA1	0.85	0.44	0.86	0.59–0.92	0.0001
	MSP1-19	0.78	0.09	0.41	0.10–0.62	0.02
	MSP2A	0.71	0.49	0.46	0.0–0.79	0.06
	MSP2B	0.86	0.36	0.90	0.71–0.95	0.0001
	MSP3A	0.72	0.28	0.63	0.24–0.77	0.007
	MSP3B	0.60	0.40	0.23	0.0–0.65	0.35
IgG3	AMA1	0.65	0.40	0.71	0.28–0.84	0.006
	MSP1-19	0.06	0.03	0.08	0.0–0.40	0.73
	MSP2A	0.71	0.49	0.61	0.24–0.86	0.005
	MSP2B	0.70	0.56	0.45	0.0–0.83	0.06
	MSP3A	0.42	0.40	0.12	0.0–0.61	0.69
	MSP3B	0.30	0.39	0	0.0–0.30	-
IgG4	AMA1	0.84	0.56	0.94	0.86–0.97	-
	MSP1-19	0.67	0.08	0.98	0.94–0.99	-
	MSP2A	0.82	0.27	0.84	0.66–0.91	0.0001
	MSP2B	0.95	0.36	0.97	0.84–0.98	0.0001
	MSP3A	0.62	0.17	0.88	0.52–0.94	0.001
	MSP3B	0.61	0.21	0.65	0.31–0.83	0.006
IgM	AMA1	0.76	0.57	0.37	0.0–0.66	0.05
	MSP1-19	0.55	0.16	0.45	0.03–0.64	0.04
	MSP2A	0.24	0.31	0.06	0.0–0.60	0.88
	MSP2B	0.48	0.27	0.54	0.0–0.74	0.14
	MSP3A	0.67	0.34	0.54	0.01–0.75	0.05
	MSP3B	0.68	0.44	0.42	0.0–0.76	0.09
IgA	AMA1	0.21	0.32	0	0.0–0.18	-
	MSP1-19	0.68	0.52	0	0.0–0.10	-
	MSP2A	0.65	0.45	0.83	0.53–0.91	0.0001
	MSP2B	0.47	0.22	0.64	0.10–0.84	0.03
	MSP3A	0.27	0.38	0.56	0.0–0.79	0.11
	MSP3B	0.33	0.24	0.39	0.0–0.63	0.33
IgE	AMA1	0.47	0.62	0.74	0.50–0.96	0.0001
	MSP1-19	0.44	0.01	0.11	0.0–0.46	0.57
	MSP2A	0	0.15	0	0.0–0.26	-
	MSP2B	0.62	0.31	0.60	0.0–0.77	0.09
	MSP3A	0.41	0.50	0.45	0.0–0.83	0.21
	MSP3B	0.81	0.10	0.92	0.63–0.96	0.003

r, Pearson's correlation coefficient; n, number of twin pairs; CI, confidence interval of h ² estimate; P values for significant heritability estimates are in bold.