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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Methods. 2009 May 6;49(2):142–147. doi: 10.1016/j.ymeth.2009.04.019

Figure 1.

Figure 1

A schematic diagram illustrating the general procedure for conducting time –resolved rapid - reaction •OH footprinting studies. In our example steps 1 – 6 were performed. The grey box indicates an additional tool for the development of ‘structural – kinetic’ models of complex folding reactions. The individual steps are explained in detail in the text and in recently published protocols [23, 25].