(A) Coronal ADC maps at the level of mid-septal nucleus and ventral postero-lateral nucleus of thalamus show larger ventricles in IVH pup than non-IVH control. B) FA maps of contiguous coronal slices of pups (day-14) with IVH and without IVH as indicated. WM structures--corpus callosum (CC), corona radiata (CR) and fimbria fornix (FF)--show decreased FA in IVH pups compared to glycerol-treated control. (C, D&E) We analyzed FA in the dominant orientation coordinates in medial-lateral(R), dorsal-ventral(G) and anterior-posterior(B) directions. FA was significantly decreased in the CC(P<0.05), CR(P<0.03) and FF(P<0.05) in IVH pups compared to glycerol-treated controls. The FA changes in CC and FF were dominant in the medial-lateral direction, whereas it was dominant in the dorsal-ventral direction within the CR. * P<0.05 for FA of IVH pups vs. glycerol-treated non-IVH pups.