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A low dose of FTY720 (0.24 mg/kg) combined with HPC provided significantly greater protection against infarct volume than HPC alone, indicative of a synergistic effect wherein HPC provides enough activation of SphK2 to phosphorylate exogenous FTY720. N-values shown in Table 1. P<0.05 vs. (*) sham PC; (#) Low FTY720; (†) HPC.
