Table I.
Metabolic effects in brains of iMSUD mice following hepatocyte transplantation
| iMSUD mice | iMSUD-HTx mice | |
|---|---|---|
| Glutamate | ↓ | ↓ |
| Glutamine | ↓ | = |
| Aspartate | ↓ | ↓ |
| Serine | ↓ | ↓ |
| Alanine | ↓ | ↓ |
| Alloisoleucine | ↑ | ↑ |
| Leucine | ↑ | ↑ |
| Isoleucine | ↑ | ↑ |
| Valine | ↑ | ↑ |
| Ornithine | ↓ | = |
| GABA | ↓ | = |
| Homocarnosine | ↓ | ↑ |
| Tyrosine | = | = |
| Tryptophan | = | = |
| Dopamine | ↓ | = |
| DOPAC | ↓ | = |
| 3-MT | ↓ | = |
| HVA | = | = |
| 5-HT (serotonin) | ↓ | = |
| 5-HIAA | ↑ | ↑ |
| 3-MT/DA | = | = |
| DOPAC+HVA/DA | ↑ | = |
| 5-HIAA/5-HT | ↑ | = |
Legend to Table: See text for metabolite abbreviations. All symbols represent comparisons to WT mice. For iMSUD mice, an equals sign (=) indicates no difference from WT mice, whereas for iMSUD-HTx mice this symbol indicates either correction or partial correction (not significantly different from WT levels).