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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2009 Aug 22;94(1):204–210. doi: 10.1016/j.pbb.2009.08.011

Figure 1.

Figure 1

Cocaine (1.0mg/kg) significantly elevated extracellular levels of DA in the caudate nucleus in four squirrel monkeys. In contrast, LY379268 (1.0-3.0 mg/kg) administration did not significantly alter extracellular DA when administered as a pretreatment to saline. However, LY379268 pretreatments significantly attenuated cocaine-induced increases in extracellular DA. The 10 min sampling intervals indicated began 60 min post probe insertion. Arrows indicate the points at which the pretreatment, cocaine or saline were administered. Data points represent mean±SEM DA levels as a percent of values obtained prior to drug administration. Abscissa: time. Ordinate: extracellular concentrations of DA expressed as a percent of baseline control levels.