Table 3.

Two groups of steroid-resistant nephrotic syndromes (SRNS) leading to end-stage renal disease in children (GBM glomerular basement membrane, Sd syndrome)

Primary idiopathic SRNS	Inherited SRNS
A multifactorial disease	A renal disease
T-cell dysregulation	Abnormal podocyte–GBM complex
Podocyte as a target	Podocyte as a disease
Idiopathic FSGS	Genetic forms of NS	Syndromic forms of NS
	Finnish type NS (NPHS1)	WT1-associated SRNS
	Other recessive FSGS	Pierson Sd, Schimke Sd
	(NPHS2, NPHS3)	Charcot–Marie–Tooth SRNS
	Dominant FSGS
	(ACTN4, TRPC6, CD2AP)
Circulating factor	No circulating factor
Immunosuppression available	No effect of immunosuppression