Table 2.
DNA damage checkpoint function in melanoma cell lines
Melanoma line | Mutation status | G2 checkpoint | G2 checkpoint |
---|---|---|---|
PMWK | WT | Defective | Effective |
Mel505 | WT | Defective | Effective |
SK-Mel-187 | WT | Defective | Effective |
RPMI8322 | WT | Defective | Effective |
Mel224 | N-RAS | Defective | Effective |
SK-Mel-119 | N-RAS | Defective | Effective |
SK-Mel-103 | N-RAS | Defective | Effective |
SK-Mel-147 | N-RAS | Effective | (Effective)1 |
SK-Mel-173 | N-RAS | Effective | Defective |
VMM39 | N-RAS | Defective | (Effective) |
SK-Mel-24 | B-RAF | Effective | (Effective) |
A375 | B-RAF | Effective | Effective |
WM2664 | B-RAF | Effective | (Effective) |
UACC257 | B-RAF | Effective | (Effective) |
SK-Mel-28 | B-RAF | Defective | Defective |
A2058 | B-RAF | Defective | Defective |
WT, wild type.
The qualification of checkpoint status as (Effective) denotes melanoma cell lines that were significantly different (P<0.05) than NHMs when adjustments for multiple comparisons were not made.