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Kaplan-Meier plot in a single patient showing the probability of arousal not occurring at different levels of chemical drive. At baseline ventilation (≈5 L/min) the probability of no arousal is very high. At some ventilation level (TA0) the probability of avoiding arousal is zero. Arousal threshold is expressed as the increase in ventilation above baseline at which the probability of arousal is 50% (TA50). Note the reduction in TA0 and TA50 following CPAP therapy in this patient.
