Figure 1. CSNO and SNAP decrease barrier function in human bronchial epithelial cells.
Effects of CSNO and SNAP (500 and 1000 μM) on (A) TER and (B) FITC-dextran (4 kDa) leakage were monitored in 16HBE14o- cells over 24 hrs. FITC-dextran permeability was assessed as apical to basolateral passage in polarized monolayers as measured by fluorescence (excitation at 492 nm, emission at 515 nm; n=4). □ = control; ▴ = CSNO 500 μM; • = CSNO 1000 μM; ▵ = SNAP 500 μM; ○ = SNAP 1000 μM.