TABLE 3.
Prepulse Inhibition in Children With 22q11 Deletion Syndrome and Sibling Comparison Subjects, Based on Eye Blinks Following Startling Auditory Pulses Presented Alone and After Prepulses
| Test Value |
Normality of Distribution |
|||||
|---|---|---|---|---|---|---|
| Group and Test Variable | Mean | SD | Minimum | Maximum | Kolmogorov-Smirnov χ2 | p |
| Children with 22q11 deletion syndrome (N=25) | ||||||
| Maximum amplitude of peak (mV) | ||||||
| Pulse trials | 3170.35 | 1435.42 | 1175.64 | 5834.31 | 0.30 | 0.99 |
| Prepulse trials | 2452.14 | 1532.03 | 168.94 | 5739.10 | 0.67 | 0.99 |
| Time of peak (msec)a | ||||||
| Pulse trials | 101.44 | 95.16 | 88.74 | 139.62 | 1.85 | 0.79 |
| Prepulse trials | 104.23 | 95.31 | 84.95 | 141.02 | 1.19 | 0.99 |
| Difference in latency (time of peak in pulse trials minus time of peak in prepulse trials) |
0.22 | 14.71 | −25.00 | 51.75 | 0.72 | 0.99 |
| Difference in maximum amplitude of peak (maximum in pulse trials minus maximum in prepulse trials) |
718.21 | 905.88 | −1055.94 | 2724.37 | 1.19 | 0.99 |
| Percentage prepulse inhibitionb | 26.06 | 29.15 | −30.55 | 85.64 | 0.67 | 0.99 |
| Sibling comparison subjects (N=23) | ||||||
| Maximum amplitude of peak (mV) | ||||||
| Pulse trials | 2947.20 | 1237.38 | 665.85 | 5792.88 | 1.46 | 0.97 |
| Prepulse trials | 1649.54 | 1052.19 | 91.19 | 4154.33 | 2.27 | 0.64 |
| Time of peak (msec)a | ||||||
| Pulse trials | 96.72 | 92.23 | 84.40 | 117.16 | 0.82 | 0.99 |
| Prepulse trials | 94.73 | 85.41 | 66.79 | 124.26 | 1.18 | 0.99 |
| Difference in latency (time of peak in pulse trials minus time of peak in prepulse trials) |
3.80 | 10.28 | −10.07 | 30.50 | 2.17 | 0.67 |
| Difference in maximum amplitude of peak (maximum in pulse trials minus maximum in prepulse trials) |
1297.66 | 862.17 | −172.17 | 2911.81 | 0.36 | 0.99 |
| Percentage prepulse inhibitionb | 46.41 | 25.60 | −5.34 | 92.52 | 1.04 | 0.99 |
a
Exponentiated log values; lower standard deviation values are given. For children with the deletion syndrome, upper SD=119.43 for pulse trials and upper SD=118.10 for prepulse trials. For sibling comparison subjects, upper SD=102.84 for pulse trials and upper SD=107.92 for prepulse trials.
b
Calculated as 100 − ([peak in prepulse trials/peak in pulse trials] × 100).