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. Author manuscript; available in PMC: 2009 Sep 29.
Published in final edited form as: Hepatology. 2009 Feb;49(2):627–636. doi: 10.1002/hep.22664

Figure 6.

Figure 6

Mcl-1flox/flox-AlbCre mice are more susceptible towards CD95-mediated liver damage. 8 (A, C–E) or 24 week old (B) Mcl-1+/+ and Mcl-1−/− mice were treated with Jo2 (0.5mg/kg) i.p. After 3h, mice were sacrificed. (A, B) Blood was collected and serum AST and ALT levels were determined. Both single (squares) and median values (bars) are presented. (C) Liver sections were stained with eosin/hematoxylin and for active caspase-3. The bar corresponds to 100μm. (D) Total liver lysates were analyzed for caspase-3 activity. (E) Apoptosis rate and architectural damage were analyzed within H/E-stained sections and were clustered into 4 groups (0: no, 1: low, 2: moderate, 3: high apoptosis rate/architectural damage). * p<0.05; **: p<0.01; *** p<0.001. RLU: relative light units.