Figure 1.

Expulsion of Trichinella spiralis in mice deficient for interleukin-4 receptor α (IL-4Rα) expression on CD4⁺ T cells (Lck^cre IL-4Rα^−/flox). Establishment and expulsion of T. spiralis was measured in (a) IL-4Rα^−/flox (BALB/c wild-type, bearing one floxed and one disrupted IL-4Rα allele), (b) global IL-4Rα^−/− and (c) Lck^cre IL-4Rα^−/flox mice at days 6 and 16 postinfection. Adult T. spiralis worms were recovered from excised intestine to determine the total worm numbers per strain. Data are expressed as the mean worm burden ±SEM. Four mice were used per group. *P< 0·05, significantly different from day 6 postinfection.