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. 2009 Sep;128(1 Pt 2):e523–e531. doi: 10.1111/j.1365-2567.2008.03022.x

Figure 4.

Figure 4

Dose–response and temporal requirements of Lactobacillus casei/Toll-like receptor (TLR) agonist combinatorial stimulation. (a) Interleukin (IL)-12p70 production by dendritic cells (DCs) stimulated with a range of concentrations (as indicated on the x-axis of the figure) of L. casei, poly(I:C), lipopolysaccharide (LPS) or combinations of L. casei plus TLR agonists. (b) Temporal requirement for L. casei/poly(I:C) or LPS synergy. TLR agonists were added to DC cultures simultaneously 4 hr after (0 hr, 4 hr) or 4 hr prior to (4 hr, 0 hr) addition of L. casei. IL-12p70 is shown as the percentage induction compared with L. casei alone. One representative experiment of three is shown.