Figure 6.

Interferon (IFN)-γ and tumour necrosis factor (TNF)-α blockades affect T effector cell accumulation. Pioneer T cells were transferred into recipients, which were simultaneously treated with anti-IFN-γ, anti-TNF-α or rat immunoglobulin G (IgG). Radioactively labelled transgenic (TG) T helper type 1 (Th1) cells were injected 24 hr later at the time of antigen application [ovalbumin (OVA)_323–339 (OVAp)/incomplete Freund’s adjuvant (IFA) and phosphate-buffered saline (PBS)/IFA]. Twenty-four and 48 hr after radioactive cell and antigen application, radioactivity was determined within the skin sites. *P < 0·05 (n = 4/group).