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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Immunol. 2009 Sep 14;183(7):4715–4722. doi: 10.4049/jimmunol.0802592

Figure 1. 12/15-lipoxygenase is involved in LPS-induced regulation of vascular permeability.

Figure 1

(A) Vascular permeability of WT mice and Alox15−/− (Alox15−/−) mice was measured 6h after LPS inhalation by the Evans blue method (n=6-7). (B) After pharmacological blockade of 12/15-LO by the inhibitor CDC (Cinnamyl-3,4-Dihydroxy-a-Cyanocinnamate, open bars) or in vehicle control mice (black bars), vascular permeability (6h after LPS) was measured by the Evans blue method. Vascular permeability in WT mice pre-treated with the 12/15-LO inhibitor or vehicle (n=4). Dotted line indicates Evans blue in saline-treated WT mice for comparison. #P < 0.05.