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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Immunol. 2009 Sep 14;183(7):4715–4722. doi: 10.4049/jimmunol.0802592

Figure 3. Hematopoietic 12/15-LO is responsible for regulation of vascular permeability following LPS-inhalation.

Figure 3

Alox15−/− mice on a CD45.2 background and CD45.1 WT mice were used in bone marrow transplant experiments. (A) Monocytes and macrophages in single cell lung preparations were identified by gating on CD45+F4/80+ cells and the percentage of reconstituted cells were shown in the histogram by CD45.2 expression (donor-derived). (B) Chimeric mice lacking hematopoietic Alox15 are protected from increased vascular permeability as measured by Evans Blue extravasation upon LPS inhalation (n ≥ 4). #P < 0.05.