Skip to main content
. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Biochemistry. 2009 Jul 7;48(26):6213–6223. doi: 10.1021/bi802146w

Figure 2.

Figure 2

Similarity of glutathione, lipoic acid, and a peptide vicinal disulfide bond. (top) Glutathione analogue γ-(H-Glu-OH)-Cys-Cys-OH(ox). (middle) Glutathione analogue 4-amino-1,2-dithiolane-4-carboxylic acid. (bottom) Overlay of the conformation of lipoic acid (white) with the same vicinal disulfide bond shown in Figure 1. Note how the S atoms of lipoic acid fit inside the ring and approximately match the positions of the S atoms of the ring. For the sake of clarity, the bond between the two S atoms of lipoic acid is omitted so that the positions of the atoms can be more clearly seen.