Table 5.

Activity of mTRΔ8 Toward Cyclic and Acyclic Substrates.

Substrate	Type of Bond Broken	Ring Size	Leaving Group pKa	Activity at 5 mM Substrateb
Lipoic Acida	S–S	5	10.7d	87.7
Lipoic Acid (pH 6.1)	S–S	5	10.7d	102
DTT(ox)	S–S	6	9.2e	0.234
PTVTGCCG(ox)c	S–S	8	8.3f	0.153
PTVTGCUG(ox)c	S–Se	8	5.2g	793
Glutathione	S–S	Acyclic	9.42h	0.0723
DTNB	S–S	Acyclic	4.75i	2430

^aThese assays were performed at pH 7.0 unless otherwise noted.

^bThe units are mol NADPH/min/mol TR.

^cThis data was taken from (26).

^dTaken from (43).

^eTaken from (44).

^fTaken from (40).

^gTaken from (36).

^hTaken from (45).

ⁱTaken from (37).