Table 6.

Activity of DmTRΔ8 Toward Cyclic and Acyclic Substrates^a.

Substrate	Type of Bond Broken	Ring Size	Leaving Group pKa	Activity at 5 mM Substrateb
Lipoic Acid	S–S	5	10.7	20.8
DTT(ox)	S–S	6	9.2	0.109
PTPASCCS(ox)	S–S	8	8.5	233
PTPASCUS (ox)	S–Se	8	5.2	514d
Glutathione	S–S	Acyclic	9.42	NDe
DTNB	S–S	Acyclic	4.75	519

^aThese assays were done at pH 7.0.

^bThe units are mol NADPH/min/mol TR.

^cThis data was taken from (26).

^dThe activity reported here is with 1 mM oxidized peptide.

^eNo detectable activity.