TABLE 1.

Laboratory Studies of a Representative Animal after Intravenous Injection of Rose Bengal Animal Q16

	Reference Range (Male Monkey Age 3–4 y)	Baseline	Day 1	Day 4	Day 7	Day 14	Day 28
Weight (kg)		6.5	6.25	6.8	7.06	7.10	7.23
Liver function
Total bilirubin	0.2 ± 0.1	0.2	0.3	0.3	0.2	0.2	0.2
ALP	529 ± 177	443	374	364	364	348 (L)	375
ALT	37 ± 9	36	35	30	31	22 (L)	28
AST	40 ± 13	35	60 (H)	33	32	31	45
GGT	57 ± 20	64	54	70	75	66	81 (H)
Total protein	7.3 ± 0.4	5.9	6.7	6.9	6.7 (L)	5.9 (L)	6.5 (L)
Albumin	4.6 ± 0.3	3.7	4.3	4.4	4.1 (L)	3.7 (L)	4.1 (L)
Electrolytes
Glucose	73 ± 16	183 (H)	61	85	64	96 (H)	32 (L)
BUN	18 ± 3	22	22	21	23 (H)	28 (H)	21
Creatine	0.9 ± 0.1	0.8	0.8	0.8	0.8	0.7	1
Phosphate	5.2 ± 0.6	4.8	5.1	5.9	5	4.8	8.2 (H)
Sodium	151 ± 9	144	145	145	146	146	147
Potassium	4.7 ± 0.6	4.2	3.4 (L)	4 (L)	3.8 (L)	4.1	4.6
Chloride	105 ± 8	108	105	106	108	106	106
Magnesium		1.3	1.4	1.5	1.4	1.2	1.8
Cholesterol	138 ± 20	112 (L)	148	139	117 (L)	122	123
Triglyceride	50 ± 16	52	16 (L)	38	97 (H)	101 (H)	58
Comment			4 + hemolysis	1 + hemolysis		1 + hemolysis
Complete blood count
Hbg	12.9 ± 0.7	11.6	12.1		11.8	11	12.1
WBC	10.5 ± 2.8	12	5.8		7.9	8.6	6
Platelets		356	291		408	354	322

H, value higher than reference range; L, value lower than reference range.