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. Author manuscript; available in PMC: 2009 Sep 29.

Published in final edited form as: J Mol Biol. 2008 Jul 1;381(1):102–115. doi: 10.1016/j.jmb.2008.05.062

(a) Comparison of the flaps of PR_G48V-DRV and of wild type PR-DRV in the two subunits. (b) Selected PR_G48V interactions with darunavir in the minor conformation. The mutant structures are colored by atom type and wild type PR is in grey. Dashed lines indicate van der Waals interactions with interatomic distances shown in Å. The arrows show the shift between the two structures with distances in Å.

(a) Comparison of the flaps of PR_G48V-DRV and of wild type PR-DRV in the two subunits. (b) Selected PR_G48V interactions with darunavir in the minor conformation. The mutant structures are colored by atom type and wild type PR is in grey. Dashed lines indicate van der Waals interactions with interatomic distances shown in Å. The arrows show the shift between the two structures with distances in Å.