Table 1.
Baseline Characteristics by Treatment Group
| 1 Sitting N= 84 |
4 Sittings N= 71 |
|
|---|---|---|
| Gender: Women - n (%) | 40 (48%) | 31 (44%) |
| Age (yrs) - Median (25th, 75th percentile) | 56 (49, 64) |
54 (45, 61) |
| Race – n (%) | ||
| White | 54 (64%) | 33 (46%) |
| African-American | 20 (24%) | 20 (28%) |
| Hispanic or Latino | 9 (11%) | 13 (18%) |
| Asian | 0 | 4 (6%) |
| More than one race | 1 (1%) | 1 (1%) |
| Diabetes Type - n (%) | ||
| Type 1 | 16 (19%) | 18 (25%) |
| Type 2 | 68 (81%) | 53 (75%) |
| Duration of Diabetes (years)- | ||
| Median (25th, 75th percentile) | 18 (13, 24) |
20 (13, 27) |
| HbA1c (%) -Median (25th, 75th percentile) | 7.7 (6.8, 9.1) |
8.2 (7.2, 10.6) |
| Prior treatment for DME in study eye - n (%) | ||
| None | 72 (86%) | 63 (89%) |
| Focal laser photocoagulation | 12 (14%) | 8 (11%) |
| E-ETDRS Visual Acuity | ||
| Median (25th, 75th percentile) – letter score | 85 (79, 88) |
83 (77, 87) |
| Central Subfield Thickness | ||
| Median (25th, 75th percentile) - Microns | 207 (191, 222) |
198 (182, 222) |
| ≥ 250 – 299 Microns - n (%) | 3 (4%) | 1 (1%) |
| Retinal Volume | ||
| Median (25th, 75th percentile) - mm3 | 6.9 (6.6, 7.4) |
7.0 (6.5, 7.4) |
|
1 Sitting N=81 |
4 Sittings N=66 |
|
|
Retinopathy Severity - n (%) (ETDRS Severity Scale)* |
||
| Mild NPDR (35) | 5 (6%) | 0 |
| Moderate NPDR (43) | 7 (9%) | 2 (3%) |
| Moderately severe NPDR (47) | 24 (30%) | 25 (38%) |
| Severe NPDR (53) | 5 (6%) | 5 (8%) |
| Mild PDR (60, 61) | 19 (23%) | 10 (15%) |
| Moderate PDR (65) | 11 (14%) | 10 (15%) |
| High Risk PDR (71, 75) | 9 (11%) | 12 (18%) |
| Cannot Grade (90) | 1 (1%) | 2 (3%) |
HbA1c: Missing 7 in one-sitting group, 13 in four-sittings group
*
Early Treatment Diabetic Retinopathy Study Research Group. Fundus Photographic Risk Factors for Progression of Diabetic Retinopathy: ETDRS report no. 12. Ophthalmology 1991; 98:823–833
Photo missing 3 in one-sitting group and 5 in four-sittings group.