Table 3.

MIC₉₀ values for besifloxacin against common causes of bacterial conjunctivitis⁷⁶,¹⁰⁶

Bacterial strain	Besifloxacin: MIC90	Comparator(s): MIC90
Susceptible S. aureusa	0.03–0.5 μg/mL	N/A
Susceptible S. epidermidisa	0.03–0.5 μg/mL	N/A
Susceptible S. pneumoniaea	0.03–0.5 μg/mL	N/A
Susceptible H. influenzaea	0.03–0.5 μg/mL	N/A
MRSA	0.06 μg/mL	N/A
Vancomycin-intermediate S. aureus	2 μg/mL	N/A
Methicillin/ciprofloxacin-resistant S. aureus	8 μg/mL	N/A
Penicillin-resistant S. pneumoniae	0.12 μg/mL	N/A
Levofloxacin-resistant S. pneumoniae	2 μg/mL	N/A
H. influenzae with β-lactamase production	0.03 μg/mL	N/A
β-lactamase–positive, ampicillin-resistant H. influenzae	0.12 μg/mL	N/A
Ciprofloxacin-susceptible MSSA	0.06 μg/mL	Moxifloxacin: 0.125μg/mL Gatifloxacin: 0.25 μg/mL
Ciprofloxacin-resistant MSSA	2 μg/mL	Moxifloxacin: 8 μg/mL Gatifloxacin:>8 μ g/mL
Methicillin-susceptible S. epidermidis sensitive to ciprofloxacin	0.06 μg/mL	Moxifloxacin: 0.125μg/mL Gatifloxacin: 0.25 μg/mL
Methicillin-resistant S. epidermidis sensitive to ciprofloxacin	0.06 μg/mL	Moxifloxacin: 0.125μg/mL Gatifloxacin: 0.25 μg/mL
S. aureus parC S80Y + gyrA S84L double mutant	0.5 μg/mL	Moxifloxacin: 0.5μg/mL Ciprofloxacin: 32 μg/mL
S. pneumoniae parC S79Y + gyrA S81Y double mutant	1 μg/mL	Moxifloxacin: 4μg/mL Ciprofloxacin:64 μg/mL

^aUnpublished data Bausch & Lomb Inc.

Abbreviations: MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-susceptible Staphylococcus aureus.