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Fig. 11. Schematic representation of the feedback control of TAK1 activity by SAPK2a/p38α and its implication for the regulation of JNK and NF-κB. (A) SAPK2a/p38α downregulates TAK1, probably via the phosphorylation of TAB1. (B) The inhibition of SAPK2a/p38α by SB 203580 (or other inhibitors of this protein kinase) abolishes this feedback control of TAK1, causing upregulation of the JNK and IKK pathways (illustrated by the thicker arrows).
