Figure 5.

Effect of SHP on UUO-induced renal interstitial fibrosis. (A) Representative images of immunohistochemistry for PAI-1, type I collagen, and α-SMA expression in UUO kidneys infected with Ad-GFP or Ad-SHP. (B) Sirius red and Masson's trichrome staining in UUO kidneys infected with Ad-GFP or Ad-SHP. Mice were killed 7 d after UUO with Ad-GFP or Ad-SHP. Magnification, ×200. Bar graphs show data obtained by computer-based morphometric analysis on day 7 after UUO. *P < 0.001 compared with control and **P < 0.01 compared with Ad-GFP (n = 5 in each group).