. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: Apoptosis. 2009 Apr;14(4):478–500. doi: 10.1007/s10495-008-0309-3

Table 1.

Parkinson disease associated genes

Gene	Locus	Inheritance pattern	Clinical phenotype
α-Syn (alpha-synuclein)	PARK1, PARK4	Dominant, or increased copy number	Duplication, A30P: typical. Triplication, A53T: atypical.
Parkin	PARK2	Recessive (partial penetrance in heterozygotes?)	Young onset, typical
UCH-L1 (ubiquitin C-terminal hydrolase L1)	PARK5	Susceptibility (dominant?)	Typical
PINK1 (PTEN-induced kinase 1)	PARK6	Recessive	Young onset, typical
DJ-1	PARK7	Recessive	Young onset, typical
LRRK2 (leucine rich rpeat kinase 2)	PARK8	Dominant, incomplete penetrance	Typical
ATP13A2	PARK9	Recessive	Atypical
HtrA2/Omi	PARK13	Susceptibility	Typical
Glucocerebrosidase/ß-glucosidase		Susceptibility	Typical