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Comparison between stochastically simulated data (circles) and calculated data (curves). A) The relatively slow polymerization of 1.0 µM ATP G-actin from N = 1 nM of 1 µm ADP seed filaments is modeled well by both the simple, single tip state model (dashed) and our multi-tip state model (solid). B) Rapid polymerization, where N is increased to 10 nM, is modeled well by our multi-tip state model but not by the single tip state model.
