Knockdown of TIP49B and INO80 leads to UV hypersensitivity. (a) U2OS cells were transfected with plasmids expressing shRNAs (sh) that target mGFP (negative control) (Supplementary Fig. 1g), YY1 or TIP49B, or both YY1 and TIP49B, for 48 h and treated with indicated doses of UV light. Survival fraction is the number of live cells after irradiation divided by the number of live cells after mock treatment and is expressed as a percentage. About 4,000 cells were counted in at least three independent experiments. Data are presented as means ± s.e.m. (b) As in a, cells were transfected with plasmids expressing shRNAs that target YY1, INO80 or both.