Table 3.

Genotype Frequencies and Relative Risks for Multiple Sclerosis in the Replication Study (BWH) and Pooled Risk Estimates

	BWH			Pooled
Genotype	Cases n (%)	Controls n (%)	RR (95% CI)*	RR (95% CI)	p-value
1/1	160 (17.6)	67 (19.8)	1.0 (0.7, 1.5)	1.2 (0.9, 1.7)	0.22
1/2	376 (41.4)	134 (39.5)	1.2 (0.9, 1.7)	1.2 (0.9, 1.6)	0.21
1/3	88 (9.7)	25 (7.4)	1.5 (0.9, 2.6)	1.7 (1.1, 2.6)	0.01
2/2	184 (20.2)	82 (24.2)	Ref	Ref
2/3	93 (10.2)	29 (8.6)	1.3 (0.8, 2.2)	1.6 (1.0, 2.3)	0.03
3/3	8 (0.9%)	2 (0.6%)	1.7 (0.3, 8.6)	2.7 (1.1, 6.4)	0.03

^*Adjusted for gender