Skip to main content
. Author manuscript; available in PMC: 2009 Sep 29.
Published in final edited form as: Curr Opin Biotechnol. 2009 Mar 4;20(1):111–118. doi: 10.1016/j.copbio.2009.02.007

Figure 3.

Figure 3

OFDI images of human Barrett’s esophagus, obtained in vivo. (A) Videoendoscope image shows islands of healthy squamous mucosa intermixed within regions of specialized intestinal metaplasia (SIM). (B) Circular transverse cross-sectional OFDI image with a layered appearance, and in some regions, an irregular surface and intraepithelial glands satisfying the OFDI diagnostic criterion of SIM. The 6 cm longitudinal segment was obtained in approximately 2 min at an acquisition rate of 9.8 frames per second (frame size: 2048 × 4096) and a pullback speed of 0.5 mm/s. (C) Expanded portion of (B) demonstrates surface irregularities (black arrowheads) and glands within the epithelium (red arrowheads). (D) Histopathologic image of the biopsy taken from the involved mucosa shows specialized and non-specialized columnar epithelium, consistent with the OFDI diagnosis of SIM. Scale bars and tick marks represent 1 mm.