Figure 4.

Pten deletion leads to enhanced migration of SEZ-born progenitors in RMS. a, Representative images of RMS stained for BrdU, P-S6, and their colocalization revealed an increase in Pten null SEZ-born progenitors migrating in RMS when compared with control and shows the BrdU⁺ population in mutant RMS is Pten null. Scale bar, 100 μm. b, Survey images of sagittal sections of control and mutant RMS stained with DCX demonstrate an increase in the number of migrating neuroblasts in mutant RMS compared with control. DAPI counter stain is used to visualize nuclei. Scale bar, 400 μm. n = 6. DCX, Doublecortin; RMS, rostral migratory stream; OB, olfactory bulb.