TABLE 2.
Comparison of rhesus and human chemokine receptor similaritya
| Receptor | Similar residues (incl. invariant) (%) | Invariant residues(%) | Similar residues (incl. invariant), Extrac. (%) | Invariant residues, Extrac. (%) |
|---|---|---|---|---|
| APJ | 378/380(99.5) | 376/380 (98.9) | 95/96 (99.0) | 94/96 (97.9) |
| CXCR4 | 350/352 (99.4) | 346/352 (98.3) | 109/110 (99.1) | 106/110 (96.4) |
| GPR15 | 356/360 (98.9) | 351/360 (97.5) | 90/93 (96.8) | 86/93 (92.5) |
| GPR1 | 351/355 (98.9) | 345/355 (97.2) | 97/98 (99.0) | 96/98 (98.0) |
| CCR5 | 348/352 (98.9) | 341/352 (96.9) | 104/106 (98.1) | 102/106 (96.2) |
| CCR2b | 354/360 (98.3) | 349/360 (96.9) | 102/105 (97.1) | 101/105 (96.2) |
| STRL33 | 332/343 (96.8) | 325/343 (94.8) | 65/74 (87.8) | 63/74 (85.1) |
| CCR8 | 344/356 (96.6) | 336/356 (94.4) | 98/105 (93.3) | 95/105 (90.5) |
| CRAM-A/B | 329/344 (95.6) | 315/344 (91.6) | 101/104 (97.1) | 98/104 (94.2) |
| CCR3 | 338/355 (95.2) | 324/355 (91.3) | 105/117 (89.7) | 94/117 (80.3) |
| CCR1 | 331/355 (93.9) | 316/355 (89.0) | 102/117 (87.2) | 90/117 (76.9) |
a
Receptors are sorted from most to least similar across entire length of amino acid sequence. Ratio reflects the number of residues that match the given criteria over the total number of residues. Predictions for which regions are extracellular (Extrac.) are based on analysis by TopPredII (see text).