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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Cancer Res. 2009 Feb 3;69(4):1279–1283. doi: 10.1158/0008-5472.CAN-08-3559

Figure 1.

Figure 1

BRMS1 up-regulates miR-146. A, ectopic expression of BRMS1 in MDA-MB-231 or MDA-MB-435 breast cancer cell lines significantly enhanced the expression of miR-146a as shown by real-time RT-PCR (∼6-fold and ∼60-fold, respectively). miR-146b expression was also increased in MDA-MB-435 (∼40-fold). B, endogenous expression levels of miR-146a and miR-146b in multiple breast-derived cell lines generally show decreased levels in tumorigenic but weakly/nonmetastatic cell lines (MCF7, T47D, and MDA-MB-436) compared with the immortalized, nontumorigenic breast epithelial cell line (MCF10A) and a further decrease was found in metastatic MDA-MB-435. Please note scale differences.