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. 2009 Aug 19;29(33):10371–10386. doi: 10.1523/JNEUROSCI.1592-09.2009

Figure 1.

Figure 1.

A, Typical voltage-clamp traces are shown for both WT and R6/2 cells from mice in each age group. B, CNQX/AP-5 application completely blocked all synaptic currents at a membrane holding potential of −70 mV. Insets show traces on a magnified timescale to more clearly show the effect of blocking ionotropic glutamate receptors. C, Mean ± SEM frequencies of EPSCs recorded in ACSF for each age group. Note the significant decrease in frequency with age in cells from WTs that does not occur in cells from R6/2 mice. D, Amplitude–frequency histograms for EPSCs recorded in ACSF for each age group. E, Cumulative probability curves for interevent interval showing a significant increase in release probability at 80 d. In this and subsequent figures, sample sizes are in parentheses, and significant differences are denoted by *p < 0.05, **p < 0.01, ***p < 0.001, and †p < 0.05 to p < 0.001.