Figure 11.

A, Typical GABA-evoked responses in dissociated pyramidal neurons from WT (black) and R6/2 (gray) mice at each age and at 10 and 1000 μm GABA. Note that, at 80 d, amplitudes are reduced in neurons from R6/2 s. B, Peak current densities at each age. Note that normalizing cells to capacitance eliminates the difference in current amplitude. C, GABA desensitization times in neurons from 40 d animals. D, Zolpidem modulation at 40 d. Typical traces from WT and R6/2 cells before and after zolpidem application.