Figure 13.

Cortical spontaneous synaptic currents in 6 (left) and 12 (middle) month YAC128 (white bars) and 12 month CAG140 KI mice (right; gray bars) and their respective WTs littermates (black bars in all graphs). A, Spontaneous EPSCs were recorded at a membrane potential of −70 mV. Distributions show amplitude–frequency histograms for EPSCs recorded in ACSF for each group. Insets show average frequencies. B, Cell membranes were voltage clamped at +10 mV and spontaneous IPSCs isolated using CNQX and AP-5. Distributions show amplitude–frequency histograms for IPSCs for each group. Insets show average frequencies.