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. 2009 Aug 19;29(33):10371–10386. doi: 10.1523/JNEUROSCI.1592-09.2009

Figure 5.

Figure 5.

Evoked EPSCs were isolated by voltage clamp at −70 mV and application of PTX (10 μm) A, Left, The relationship between stimulus intensity and EPSC amplitude was identical in WT and R6/2 mice at 21 d. Right, Typical traces from WT and R6/2 neurons at 21 d. Stimulus artifacts have been attenuated for clarity. B, Left, Paired-pulse ratios for intervals between 25 and 400 ms were unaltered at 21 d. Right, Typical paired-pulse responses at 25, 50, and 100 ms intervals in neurons from mice at 21 d. C, Left, Relationship between stimulus intensity and evoked EPSC amplitude at 80 d. Right, Typical EPSCs evoked at 0.04 and 0.08 mA stimulus intensities in WT and R6/2 neurons. D, Left, Paired-pulse profiles from WT and R6/2 neurons. Right, Typical paired-pulse responses at 25, 50, and 100 ms intervals from both WT and R6/2 pyramidal neurons. Note: All x-axes for stimulus intensity plotted on a log-scale. Dashed lines indicate levels for PPF (ratio >1.1) and PPD (ratio <0.9).