Table 1.
Basic membrane properties pyramidal neurons in slices from R6/2 mice
| 21 d (CsMeth) |
40 d (CsMeth) |
80 d (CsMeth) |
80 d (KGluc) |
|||||
|---|---|---|---|---|---|---|---|---|
| WT (n = 35) | R6/2 (n = 44) | WT (n = 19) | R6/2 (n = 21) | WT (n = 28) | R6/2 (n = 35) | WT (n = 11) | R6/2 (n = 12) | |
| Rm (MΩ) | 110 ± 5 | 104 ± 6 | 131 ± 13 | 133 ± 12 | 173 ± 10 | 178 ± 10 | 135 ± 23 | 221 ± 16** |
| τ (ms) | 2.7 ± 0.1 | 2.9 ± 0.1 | 2.6 ± 0.2 | 2.5 ± 0.2 | 2.1 ± 0.2 | 2.0 ± 0.1 | 2.2 ± 0.2 | 1.8 ± 0.2 |
| Cm (pF) | 150 ± 7 | 146 ± 5 | 122 ± 7 | 129 ± 6 | 107 ± 6 | 101 ± 4 | 145 ± 13 | 99 ± 6** |
| RMP (mV) | −73.1 ± 1.6 | −65.3 ± 2.9* | ||||||
| APthreshold (mV) | −44.1 ± 1.7 | −45.5 ± 3.8 | ||||||
In each column, data for WT and R6/2 are presented at the ages indicated. Internal solution and n values are indicated in parentheses. Significance is indicated by *p < 0.05; **p < 0.01. APthreshold, Action potential threshold.