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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Biochemistry. 2009 Aug 25;48(33):7777–7779. doi: 10.1021/bi9011622

Figure 1.

Figure 1

Transition-state schematic and activity profiles for adenosine and N1-deazaadenosine at positions 9 and 10. (A) Transition-state stabilization of small ribozymes. (B) Single-turnover cleavage of adenosine and N1dA at position 9 and 10 of the HPRZ crystallization construct (Figure S1). The reaction was monitored for 4 h. Inset: bases at 9 and 10 of this investigation.