Table 1.
Diagnosis | No. Cases | Prior Tx |
---|---|---|
Peritoneal mesothelioma | 5 | 1–3 (2) |
Pleural mesothelioma | 9 | 0–4 (2) |
Pleural-peritoneal mesothelioma | 2 | 1–3 (2) |
Ovarian cancer | 7 | 2–9 (6) |
Pancreatic carcinoma | 1 | 1 |
Total | 24 | 0–9 (2) |
Dose levels of SS1P | No. Enrolled | No. Patients with DLT |
4 µg/Kg/day ×10 | 3 | 0 |
8 µg/Kg/day ×10 (3) | 3 | 0 |
12 µg/Kg/day ×10 (3) | 6 | 1 |
18 µg/Kg/day ×10 (3) | 6 | 0 |
25 µg/Kg/day ×10 (3) | 6 | 1 |
Ages: 31–69, median 60 | ||
Males: 13, Females: 11 |
DLT, dose-limiting toxicity, Prior Tx, number of prior chemotherapy regimens per patient, range (median).