Table 1.
Characteristics of Patients with SLE and Control Subjects
| CHARACTERISTICS | Patients with SLE (n=113) | Control subjects (n=80) | P VALUE |
|---|---|---|---|
| Age (years) | 40 (31–47) | 41 (30–49) | 0.98 |
| Female (%) | 92% | 86% | 0.23 |
| White race (%) | 67% | 73% | 0.53 |
| Current Smoking (%) | 25% | 24% | 1.0 |
| Pack/years of smoking | 0 (0–5) | 0 (0–0.7) | 0.26 |
| Diabetes (%) | 4% | 3% | 1.0 |
| Hypertension (%) | 45% | 16% | <0.001 |
| Body Mass Index (kg/m2) | 27.3 (23.8–33.2) | 25.2 (22.1–30.0) | 0.04 |
| Family history of early CAD (%) | 19% | 11% | 0.16 |
| Total cholesterol (mg/dl) | 165 (141–204) | 180 (154–206) | 0.13 |
| Low-density lipoprotein (mg/dl) | 96 (78–129) | 108 (89–137) | 0.04 |
| High-density lipoprotein (mg/dl) | 48 (36–55) | 47 (38–61) | 0.58 |
| Homocysteine (μmol/L) | 9.2 (7.3–11.1) | 7.6 (6.5–8.9) | <0.001 |
| Augmentation index¶ (%) | 25 (21–32) | 21 (12–29) | 0.04 |
| White blood cells (per/μl) | 5,600 (4,300–7,700) | 6,000 (4,900–6,900) | 0.45 |
| Platelets (thou per/μl) | 244 (211–299) | 267 (232–312) | 0.07 |
| Creatinine (mg/dl) | 0.8 (0.7–0.9) | 0.8 (0.7–0.9) | 0.84 |
| Estimated glomerular filtration rate (ml/min/1.73 m2) | 95 (79–109) | 91 (82–104) | 0.80 |
| Triglycerides (mg/dl) | 103 (71–150) | 81 (62–108) | 0.03 |
| Lipoprotein (a) (mg/dl) | 12 (5–37) | 11 (5–32) | 0.71 |
| TNF-α (pg/ml) | 4.8 (3.1–7.9) | 2.4 (1.8–3.0) | <0.001 |
| IL-6 (pg/ml) | 5.7 (2.3–22.4) | 1.8 (0.9–4.7) | <0.001 |
| Coronary calcification (Agatston Units, mean±SD) | 43.4±189.8 | 3.8±27.9 | 0.002 |
¶
Data available in 60 patients with SLE and 42 control subjects