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. Author manuscript; available in PMC: 2009 Oct 3.
Published in final edited form as: Cell. 2009 Apr 3;137(1):47–59. doi: 10.1016/j.cell.2009.01.038

Fig. 5. Nurr1 suppresses inflammatory mediators in murine astrocytes.

Fig. 5

A and B. Expression of IL1R1 (A) and p55TNFR (B) mRNA in primary astrocytes and microglia as determined by qPCR assay. *, p<0.01. C. Responses of primary mouse microglia or astrocytes to TNFα or IL1β for 6h. iNOS mRNA level was determined by qPCR. D. Regulation of Nurr1 mRNA in mouse primary astrocytes stimulated with TNFα or IL1β for the indicated times. E–I. Effect of knockdown of Nurr1 in astrocytes on induction of NO (F – measured by Greiss reaction) and mRNAs encoding neurotoxic mediators (E, G–I). Mouse primary astrocytes were infected with shCtrl- or shNurr1-lentivirus and cells were stimulated with TNFα or IL1β for 6h.