Table I. Comparison of nucleolar-disrupting activity of various agents and their p53 activation capability.

Agent	Nucleolar disruption	Reference	p53 stabilization	Reference
UV	✓	Zatsepina et al. (1989)	✓	Pluquet and Hainaut (2001)
Cis-Pt	✓	Jordan and Carmo-Fonseca (1998)	✓	Pluquet and Hainaut (2001)
5-FU	✓	Ghoshal and Jacob (1994)	✓	Pritchard et al. (1997)
DRB	✓	David-Pfeuty et al. (2001)	✓	David-Pfeuty et al. (2001)
Actinomycin D	✓	Haaf and Ward (1996)	✓	Andera and Wasylyk (1997)
α-Amanitin	✓	Haaf and Ward (1996)	✓	Andera and Wasylyk (1997)
Camptothecin	✓	Buckwalter et al. (1996)	✓	Ljungman (2000)
NTP depletion	✓	Grummt and Grummt (1976)	✓	Linke et al. (1996)
Bleomycin	✓	Vazquez-Nin et al. (1979)	✓	Pluquet and Hainaut (2001)
Heat shock	✓	Y.Liu et al. (1996)	✓	Ljungman (2000)
Hypoxia	✓	Yung et al. (1991)	✓	Graeber et al. (1994)
LMB	–	–	✓	Freedman and Levine (1998)
MG132	–	–	✓	Klibanov et al. (2001)