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. Author manuscript; available in PMC: 2009 Oct 30.
Published in final edited form as: J Neurosci Methods. 2009 Jul 21;184(1):142–151. doi: 10.1016/j.jneumeth.2009.07.005

Figure 2.

Figure 2

(A) Schematic representation of the electrode-brain interface (EBI). We defined the EBI as consisting of the DBS electrode, the surrounding tissue, and a peri-electrode space whose properties change over time. The EBI can also be represented by an equivalent circuit (A right). (B) This can be modelled using a 2-dimensional axi-symmetric representation as this geometry is symmetrical along the axis of the electrode, which has the advantage of using less computational power to simulate. (C) However, a 3-dimensional model represents the precise geometry of the electrode, located within a cylinder of surrounding tissue which is centred on the tip of the electrode but orientated along the axis of the anatomical details included, in this case the third ventricle and cerebral aqueduct. Such FEM models were combined with axon models, which can be orientated perpendicular to both the electrode shaft, and the plane of the axi-symmetric model (red/white circles).