Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Sep 22;16(1):88. doi: 10.1186/1423-0127-16-88

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2009 Sivasubramaiyan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Trophoblast differentiation from embryoid bodies on the biomimetic platform. Panel (a) shows a non-cystic early EB. Panel (b) shows a late cytic EB with clear fluid filled cavity (red arrow) and a small mass of cells similar to inner cell mass (ICM) of an embryos (green arrowhead) pushed towards the top. Panel (c) shows a cystic EB outgrowing on the biomimetic platform on day 16. Panels (d) and (e) immunolocalization of trophoblast markers cytokeratin 8/Troma1 (red) and SSEA1 (green) in cytic EB outgrowths at early day 8. Blue (DAPI stain) represent the nuclei. This shows the evidences for the first signs for clear and distinct trophoblast cell differentiation from cystic EBs as early as day 8.